Biomimetic Heparan Sulfate-Like Coated ePTFE Grafts Reduce In-graft Neointimal Hyperplasia in Ovine Carotids
نویسندگان
چکیده
منابع مشابه
Paclitaxel-coated expanded polytetrafluoroethylene haemodialysis grafts inhibit neointimal hyperplasia in porcine model of graft stenosis.
BACKGROUND The main pathology of haemodialysis graft stenosis is venous neointimal hyperplasia at graft-venous anastomoses. Neointimal hyperplasia is also observed in cases of coronary artery in-stent restenosis. Paclitaxel is a chemotherapeutic agent used to treat cancer, and has been proven to inhibit neointimal hyperplasia of coronary artery in-stent restenosis. In this study, we examined wh...
متن کاملMyointimal hyperplasia in vein collars for ePTFE grafts.
OBJECTIVE To understand the cause of intermediate ePTFE graft failure when a venous boot is used. This might give insight into the improvement in patency that results from the use of a venous boot. DESIGN A histological and radiological study of failed and failing grafts. METHODS A review of patients operated upon in St Mary's Hospital under the care of a single consultant. RESULTS Four a...
متن کاملMethotrexate loaded SAE coated coronary stents reduce neointimal hyperplasia in a porcine coronary model.
OBJECTIVE To evaluate the effect of stent based methotrexate delivery on neointimal hyperplasia. METHODS Stainless steel coronary stents and biological polymer coated (SAE) stents were randomly implanted in coronary arteries of pigs with a stent to artery ratio of 1.1:1. The pigs were killed after five days (10 stents) or four weeks (20 stents). Second, stainless steel coronary stents were di...
متن کاملIncreased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased blood flow on intimal hyperplasia in porous polytetrafluoroethylene grafts implanted in baboons. These grafts develop an endothelial lining by 2 weeks and neointimal thickening due to proliferation of underlying smooth muscle cells by 1 mont...
متن کاملBiological effects of anti-CD34-coated ePTFE vascular grafts. Early in vivo experimental results
AIM OF THE STUDY To assess the biological activity of anti-CD34 antibody-coated ePTFE vascular prostheses. MATERIAL AND METHODS Indium(111)-labeled autologous thrombocytes were administered to 5 anesthetized pigs after the placement of femoral arterial and venous catheters. An arterio-venous fistula, created by the random interposition of 4 different ePTFE grafts (A = dry control, B = dry ant...
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ژورنال
عنوان ژورنال: Annals of Vascular Surgery
سال: 2017
ISSN: 0890-5096
DOI: 10.1016/j.avsg.2016.09.015